The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. The liver and kidneys excised from all the experimental rats were fixed in a labeled sample bottles containing 10% formalin and processed for histological examination. Joseph, H., Gleye, J., Moulis, C., Mensah, L. J., Roussakis, C., and Gratas, C. Justicidin B, a cytotoxic principle from Justicia pectoralis. 1972;47:38994. Another plant with this benefit is fertility tree. Ani, Onuabuchi & Udedi, Stanley & Asogwa, Kingsley & Enemali, Michael & Onwelumadu, Chigozie & Ikedife, Kenneth. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. Current School News In a reaction mixture containing 0.01M phosphate buffer (pH7.0), 0.5ml of 0.2M H2O2 and 0.4ml distilled water, 0.5ml of sample was added. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Excitedly, scientific studies have supported the traditional claims. These antibodies help prevent infections and fight off diseases. These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. Faiza R, Waqas KK, Adeel M, Muhammad G. Detection of bioactive fractions of Justicia adhatoda leaves. Kidney weight of rats treated with JCEE showed no significant difference with exception in 800mg/kg JCEE that demonstrated significant reduction. The absorbance of the supernatant was measured against reagent blank at 532nm. Venancio, E. T., Rocha, N. F., Rios, E. R., Feitosa, M. L., Linhares, M. I., Melo, F. H., Matias, M. S., Fonseca, F. N., Sousa, F. C., Leal, L. K., and Fonteles, M. M. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor. The leaves are also rich source of vitamin A, vitamin C, and vitamin E. Another plant with this composition is pumpkin fruit. Liver and kidney are the main targets of toxicants because they are respectively involved in biotransformation and excretion of xenobiotics. J Nat Prod 1988;51(3):599-600. long (20 cm), densely packed with pink to crimson tubular flowers. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. Yes my readers. The Hematological system and antioxidant status of rats following 14days of sub-acute exposure tolerated the ethanol extract of J. carnea leaf. Olaniyan JM, Hadiza LM, Hussaini AM, Musa BB, Abubakar SA. Some vitamin composition of Justicia carnea leaves The antioxidants in Justicia carnea helps protect the liver and the heart from toxic agents and free radicals. When properly boiled in water, the aqueous leaf extract turns red, and when mixed with milk turns pink. Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves With exception of low doses that showed normal morphology of the hepatocyte and sinusoid that is not infiltrated, high doses of extract greater than 500mg/kg showed mild fat congestion in the central venules with liver parenchyma showing area of hemorrhage compared to the control. This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. However, lowest (50mg/kg) dose of extract significantly elevated MCH and MCHC. J Ethnopharmacol 1985;13(1):3-49. Absorbance reading was taken at 620nm regularly at an interval of 1min against reagent blank. Ewe eje isn't capable of causing any side or negative effects if consumed moderately. View abstract. Nigeria's medicinal plant: Justicia carne (Ewe eje) The leaves of Justicia carnea contains powerful antioxidant activities and phytochemical components that help reduce oxidative stress, and reduce the risk of development of cancer. Leaf extract in isoproterenol induced myocardial infarction in albino rats. Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. Dyslipidemia is one of the risk factors of cardiovascular diseases. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. CAS Prof. F.O. No. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. 1.3.1 Aetiologyof Anaemia Anaemia may be due to a single factor such as a nutritional deficiency or multifactorial (McEvoy, 2013). Phytochemical profile, antioxidant, -amylase inhibition, binding The gradual decrease in the weight of organs following short-term exposure of J. carnea leaf ethanol extract may be attributed to adaptive response of the organs arising from daily dosage of the extract or its metabolites within their body. Two of the most important soil considerations include fertility and drainage. This claim by traditional healers with regard to the efficacy of justicia carnea in the treatment diabetes have been researched on and it was found to be true. The flowers are slightly fragrant and mostly sterile. So lets go through this together. CAS et al. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. Macrocytic and hypochromic anemia usually results due to increased mean corpuscular volume (MCV) and decrease in mean corpuscular hemoglobin concentration [30]. It has been reported previously that under certain conditions, dietary antioxidants such as ascorbic acid, tocopherol and carotenoids could act, occasionally, as pro-oxidants to initiate slight degree of oxidative stress microenvironment. WBC reduced in rats treated with doses of J. carnea with significant decrease (p<0.05) in rats that received 50, 100 and 1200mg/kg body weight. Microsomal lipid peroxidation. All rights reserved. Adetuyi is a Professor of Biochemistry in the Department of Chemical Sciences, Faculty of Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. The resultant liquid would turn crimson red. Aim. Sun M, Zigma S. An improved spectrophotometer assay of superoxide dismutase based on epinephrine autoxidation. A., Bezerra, G. A., Matos, F. J., and Viana, G. S. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. Saunders; 1995. p. 26873. Washington, DC: The National Academies Press; 1997. https://doi.org/10.17226/4988. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. PDF Haematological and Biochemical Studies on Justicia Carnea Leaves Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. While the renal tubules across the tested groups were normal with the interstitial spaces showing moderate congestion and hemorrhage, there appeared some abnormalities in the renal cortex (such as few sclerotic glomeruli with moderately dilated capsular spaces) resulting in fair architectural structure of the kidney (Fig. This is due to the inability of the pancreatic beta cells to secrete insulin, which transports glucose to cells, or the inability of cells of the body to recognize insulin. I am a practicing medical doctor, a philosopher, critical thinker, a globalist, a patriot, SEO expert and a patient blogger. Mr. E.S. Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. 1. Technical guidelines assembly of veterinary medicine research. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). https://doi.org/10.35841/biomedicalresearch.30-18-666. J. Pharmacogn. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Nutritional Composition of Ewe eje (Justicia carnea leaf). One of the symptoms of diabetes is elevated blood glucose level. 2015;174:61827 https://doi.org/10.1016/j.jep.2015.06.005. It is obvious that Justicia carnea has potential antianemic, antioxidant, antidiabetic, hepatoprotective, and immune-boosting properties. Aside boosting blood production in normal persons, justicia carnea leaves also reverses anemic conditions. B-vitamins are good sources of energy. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). Paes-Leme AA, Motta ES, De Mattos JCP. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. 4. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. It creates the perfect environment for aphids and dried sod. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). 50mg/kg-1200mg/kg treatments relative to control showed varied degree of hepatic injury that is dose dependent. https://doi.org/10.1016/j.jep.2005.06.013. Authors KOK and ESA performed the statistical analysis and managed the analyses of study. what are the pros and cons of testosterone replacement therapy? Deleting this collection CANNOT be undone. The blood stimulating effects could be due to the presence of dietary bioactive constituents that stimulate activities of haematopoietic cells and stabilization of blood in circulation [21]. Biomed Environ Mass Spectrom 1988;15(8):413-417. Guide to Jacobinia/Justicia Carnea - How to Grow This Plant - Gardenzy Keep in mind that natural products are not always necessarily safe and dosages can be important. Karigidi is a lecturer in the Biochemistry unit of Chemical Sciences Department, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria. Justicia carnea is a medicinal plant that is used conventionally as blood tonic from time immemorial in Nigeria. Also, remove old flowers to keep the plant healthy. Note: A=change in absorbance, TV=total volume, SV=sample volume, =molar extinction=4020M1cm1, TP=total protein. Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. W Afr J Biol Sci. 1999;9:18. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. 10.17306/J.AFS.2017.0492. Paradoxically, oxidation of GSH has been reported to occur when GSH interact with metal ions thereby generating superoxide anions from the transfer of electrons from the metal ions to molecular oxygen [32]. Research reports it isn't capable of . de Vries, J. X., Tauscher, B., and Wurzel, G. Constituents of Justicia pectoralis Jacq. Ethanol extracts of J. carnea leaf increased RBC, hemoglobin and platelet with significant increase (p<0.05) in groups that received higher dose (>500mg/kg b.w) of extract compared to the control. J Ethnopharmacol. Part shade is the ideal growing condition for Brazilian plumes. Mapanga RF, Musabayane CT. The present study investigated the antioxidant and in vitro antidiabetic capacities of Justicia carnea aqueous leaf extract (JCAE) using -amylase inhibition model. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. [4].Inflammationinjuries, in an attempt to heal is presented by five cardinal signs of heat (calor), redness (rubor), swelling (tumor), pain (dolor) and loss of function5.Studieshave demonstrated inflammation as being caused by This is not a big concern as it wont kill the plant and you will find a solution at your local gardening center. Provided by the Springer Nature SharedIt content-sharing initiative. They can easily tolerate acidic to slightly alkaline sandy, loamy, and clay soils. Anal Biochem. While graded doses of J. carnea ethanol extract showed no significant difference in the liver and kidney GSH compared to the control, only rats that received 1200mg/kg body weight JCEE statistically decreased in the kidney. The plant is hardy to USDA Hardiness Zones 8b through 11. The plume flowers grow atop a crown of foliage in large dense clusters. 2015;15:236. https://doi.org/10.1186/s12906-015-0760-y. 1978;52:30210. As reported by science, Justicia carnea is composed of secondary metabolites such as: flavonoids, terpenoids, alkaloids, phenols, saponins and tannins. Justicia carnea is a popular ornamental plant, which possesses powerful medicinal values. Although, medically, it is advised you see your doctor or a physician before using the leaf for medicinal uses. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. But like in the case of depression and hepatitis, other species of justicia have been studied and proven to be antiepileptic. https://doi.org/10.3390/molecules191221442. Walters DM., Cho Hye-Youn, Kleeberger SR. Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2. 15 Amazing benefits of brocoli juice and side effects. 9 health benefits of justicia carnea - Herbconer Cardioprotective role of Justicia traquebareinsis Linn. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. Niger J Physiol Sci. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. A cup of water Nutritive properties of aqueous extract Justicia carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male wistar albino rats. Justicia pectoralis is a flowering herb that grows in tropical areas of the Americas, including South and Central America. When you boil the plant, it turns the water red. Becoming a contributing member of Gardenia is easy and can be done in just a few minutes. Decreased white blood cell count was obtained in this report, the level of lymphocyte and granulocyte was not altered by the extract while MID sized cell was significantly elevated at 500 and 800mg/kg dose. PubMed Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. This special leaf can be found around us- in our neighborhood. PubMedGoogle Scholar. National Research Council. The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. The higher LD50 (>5000mg/kg body weight) of J. carnea leaf ethanol extract suggested that the ethanol extract is experimentally safe and not toxic. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. Article ID 687197, 2013; p. 13. https://doi.org/10.1155/2013/687197. Pompella A, Visvikis A, Paolicchi A, De Tata V, Casini AF. Check these Great Plant Combination Ideas with Justicia, Eye-Catching Retaining Walls and Staircases, An Eye-Catching Mediterranean Garden with Agave, Aloe and Pincushion, A Striking Water-Wise Border with Agave, Cactus and Ocotillo, A Beautiful Duo with Agave 'Blue Flame' and 'Blue Glow', A Long-Lasting Summer Garden Idea with Marigold and Sage, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, H1, H2. Details on Purple Shield plant care. Onyeabo, Chimaraoke & Achi, Ngozi & Chima, Ekeleme-Egedigwe & Ebere, Chidinma & Okoro, Chidinma. Why urban citizens in developing countries use traditional medicines: the case of suriname. This requires more attention to properly document the various health benefits of justicia carnea. Studies have also confirmed this claim. Braz. It is also composed of vitamins and minerals good for heart health. White blood cell counts usually increases following foreign invaders (pathogens) resulting in normal body physiological response which boost the bodys defense mechanisms [28, 29]. Justicia carnea does not cause miscarriage or congenital birth defects. and M.Sc. 2010;4(8):6804 https://doi.org/10.5897/JMPR09.487. In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. One of the health benefits of justicia carnea is in boosting immune system. Justicia carnea (Brazilian Plume) is an upright, evergreen shrub with large, dark green leaves, 10 in.