That sounds a lot like my dr. Its basically an assembly line in there. I honestly wish I had but thats all hindsight now knowing what I knew. I felt like a number in his practice, and I think he was milking my insurance for all he could get. In this post well learn more about IVF with PGS success rates for euploid embryos. Medication wise other than the standard progesterone and estrogen and prenatal I also did take aspirin 81mg. I have to say that I'm not 100% sure I needed any of the extra things we did- but I wanted to try whatever I could and these things couldn't hurt. Last January we found out we were pregnant but had a miscarriage at 7 weeks. I encourage to keep pushing forward. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. Note that once you confirm, this action cannot be undone. Would you ladies push next time for a different protocol? I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. My RE felt that having one good embryo was not a guarantee, so 4 rounds of retrievals it took before we had a few to work with. Consult with your doctor before making any treatment changes. Your experience is so inspiring, thank you for sharing . Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. My doctor really only wants me to transfer one embryo, my husband and I want to do 2. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. I only have embryo left ugh . It worked and now I'm 24 weeks pregnant with twins! PGS testing done this round 8 high quality normal embryos. Im trying not to fixate on my last embryo being a day 7. They also reported the number ofblastsbiopsied. This November I did a frozen transfer with an untested, five day embryo and Im 9 weeks now. Im going to try and run it by her again to see what she thinks. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. I dont know if this is helpful or not but Ive had 4 FETs. An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. Best of luck to you. What are the miscarriage rates with PGT embryos? : r/IVF - Reddit Terms are highlighted every 3rd time to avoid repetition. During my first IVF cycle, when we only created 2 normal embryos out of 18 eggs (my husband's sperm is great), it seemed like embryo quality would have explained the first two chemical pregnancies. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. amazing, that gives me hope :) thanks so much! I have a whole page dedicated to mosaic embryos. Why I Gave My Mosaic Embryo a Chance - The New York Times Poor quality embryos are they worth PGS testing? Check here for the full. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. 12 43 comments Best Add a Comment gundacurry 2 yr. ago https://www.fertstert.org/article/S0015-0282 (17)31371-7/fulltext lennylincs 2 yr. ago Feeling more confused than ever. Check here for the full glossary (please excuse the repeated terms!). Multiple losses due to chromosomal abnormality, did you do ivf? My FET is at the beginning of June so hoping that with this adjustment, a better outcome will occurs. Best of luck to you!! Its so heartbreaking but Im trying to find some hope so I can move forward. If it's any consolation, we also did acupuncture with the failed FET, but not the one that worked. I was completely devastated because I never thought that would happen with a PGS. Aww happy your second round worked! My doctor told me you can have an infection in the uterus and have no symptoms. I had also changed from an estradiol tablet to estradiol patches in my first FET. Do embryo biopsies for PGT-A match the rest of the embryo? As for boosting chances with two put back it should not be the trick. I hope this gives you some hope. Thats what i needed to hear. They also did a subgroup analysis using this data for age groups <35 and >35. While I know my struggles are not unique I still feel so alone in this journey. Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. I have a similar story. Ive done intralipid infusions and Neupogen each time in the case I had an autoimmune disorder or natural killer cells so I dont think that would be the issue. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. ERA testing: Hi lovely people , as per - Fertility Network UK yes! I am terrified he wont implant. Just trying to figure out what else I can do as I only have one embryo left. Once they see it on an U/S, I think it becomes a clinical pregnancy. Go figure, right?! All 3 embryos made it to day 5 blastocyst on the 6th day we did pgs testing. Or is it worth having the actual tests done? Another thing to consider: Has your doctor done a hysteroscopy? Thanks! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome.So no one knew what was being transferred. what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . Would love to hear if it was successful - fingers crossed . So all the aneuploid embryos that were transferred either didnt implant, or miscarried. And Im so sorry about your first FET. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus. My current success was a FET with NO meds except vaginal progesterone. We timed everything to my cycle. Trying naturally, assisted, etc. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. Hi all, (2014)found no difference inongoing pregnancybetween grades (about 50% for each category). I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. Im so sorry youre going through that. We were hoping for a Christmas miracle however that was short lived. Chemical Pregnancy: What it is, Symptoms, and More - WebMD Im surprised there are still doctors out there who do not bring up this protocol. I also did Neupogen but they still wanted to test for autoimmune disorders. Liebermann et al. She said she is willing to do so but against her medical advice. Talk about adjusting meds? I actually didnt have embryos to bring with me when we switched. Jun 13, 2021 2:33 PM It is looking like we will have a second consecutive blighted ovum with a PGS normal embryo. I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. Im sure that data exists especially since thats how things used to be done back in the day. IVF is a numbers game. Good luck and wishing baby dust your way soon! Question about blastocysts and PGS testing - we got 12 eggs / 7 mature / 7 fertilized with ICSI and 2 grew to 6 days. Terms are highlighted every 3rd time to avoid repetition. It is seriously invaluable to me. Im absolutely going to ask for biopsy and check for endometritis. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). Best of luck to you. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. no, I just took those 3. My husbands sperm analysis was only very slightly abnormal. , Ive done embryo glue every transfer but no luck unfortunately :(. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. Hello, We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. PGS or Transfer 2 embryos? - Infertility - Inspire A recent meta-analysis by Simopoulou et al. Now I wonder if that could have been the culprit. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? HCG was 24 Friday and yesterday went down to 16. Use of this site is subject to our terms of use and privacy policy. We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. Segmental aneuploids: the main source for PGT-A false positives? (2017)had similar results to above (aCGH, women <35): Capalbo et al. I was exactly like you- I told myself and my RE that I refused to go through that devastation again so I wanted to do everything possible to make the outcome different. I dont see myself spending a fortune on acupuncture again. (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). About 7 months later I transferred a day 7. The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. That is, you definitely need an embryo with normal chromosome, but it's not the only variable to consider. If you haven't had multiple losses/failed attempts feel free to comment but please be empathetic when doing so. Wishing you the best of luck and baby dust. How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. My second Beta I dropped to 59. That said, Im still glad that I pursued additional testing and second opinions just in case. PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). Hi, i didnt have chemicals, I had bfn for my first two transfers. When questioned as to why nothing was working, his response was sometimes it just doesnt happen and we dont know why. This can be done! I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. https://www.remembryo.com/embryo-news-pgs-testing-doesnt-improve-success-in-good-prognosis-patients/. We decided to see an RE given our age. Our RE recommends trying again, but it feels like insanity to try the same thing without changing/adding anything or doing some tests. It was a chemical pregnancy. I actually didn't do acupuncture the second cycle, but I was in great shape. Thanks! No PGS testing But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. The RE I ended up with said "lets fight for this!" Disclaimer: Any studies presented here may be contradicted by other studies. I am so so sorry. Check mycomplete guide to mosaic embryosto learn more about mosaics, or mycomplete guide to PGT-Ato get more background on PGT-A (akaPGStesting). After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. We have not done a hysteroscopy but will ask my dr if we can do one to check and at least rule that out. While those are great odds, sometimes the FET fails. Sounds like a beautiful a rainbow miracle! Endomitritis is basically an inflammation in the uterus that makes it inhospitable for an embryo to implant or grow. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Only one normal PGS embryo - any advice on preparing for - Inspire We decided to start with IUI with clomid which resulted in another chemical pregnancy. He also answers questions in his private Facebook group. PGS enhances the success of IVF but not in all cases; the success rates vary by age. Thanks for commenting! Low hCG levels. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Best of luck to you. Id say if you feel you want the extra testing, push for it. Ill come back and edit this post with the link. We started some workup with my OB (TSH, karyotyping and carrier testing). The Munne et al. hang in there. Good luck to you on this journey and I hope round 2 is successful for you!! We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. I cannot even imagine how it mustve been to go through all of that but Im happy to hear you finally got your miracle!!! Yes, and I believe it was due to doctor negligence. I think whats missing is the success rates for transfers of non PGS tested embryos. Youre right! Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. I also tested positive for anti-thyroid antibodies. Thanks in advance! Setting: University-based fertility center. Some of the reasons quoted weren't even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, there's a margin of error with the testing itself, pgs doesn't tell us everything about an embryo, etc. 4 PGT-M and PGT-A vs. Prenatal Testing And demand that my lining be over 8 before I allow another transfer to occur? Overall, I really wish clinics and REs were more straightforward about odds of success esp with pgs since I think they can be a little misleading. My 2nd also failed and I had them do a thrombophilia panel on me and found I had a MTHFR mutation so we added folgard and he adjusted my days on progesterone and in addition to the suppositories I did the shots as well. Good luck! If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. If you have not I would suggest an embryo scratch/biopsy before your next FET. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. Your post will be hidden and deleted by moderators. Has anyone experienced a failure or chemical pregnancy when transferring a PGS normal embryo *AND* being on an autoimmune protocol? My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. We have one day 7/Euploid Blast 5BB remaining on ice. Congratulations on your pregnancy xxx With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. How many of your embryos made it to day 5? The Bump Note that this is per transfer data. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. I've experienced 3 chemical pregnancies - one naturally (7/2017), one via our 2nd IUI (9/2018), and the third this January after our FET with a PGS tested embryo. And congrats on your little girl! Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. Praying you did and thank you for the advice! Criticisms of PGS - FertilityIQ A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). Well start with euploids, then mosaics, and end with fully aneuploid embryos. Should I just ask for this to be done regardless? We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. He was surprised my doctor was doing a Receptiva test naturally, without medication, since the idea is to simulate the same environment of a transfer, and was also surprised that my doctor had done a 5-day-post-retrieval-transfer in the first place. I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. I find the live birth rates by transfer versus by retrieval data very interesting. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). My current doctor did mention surrogacy as well, especially since the embryo we brought over was our final attempt with IVF. And since then Ive had medical issues that havent allowed me to try again until last month. Chemical pregnancy facts. I'm in a similar situation so will ask my RE about all of this! According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. also did you have to do another stim cycle? ALL THREE DID!!! We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". Maybe the wash too? Hi, sorry about your 1st FET chemical. All the comments on here seem pretty helpful already. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. I'm sure that is REALLY frustrating to have a loss after spending all that money to get "good" embryos. How does PGS improve IVF success rates? - Infertility Aide We had 30 eggs retrieval. Your clinic may have a better idea! While a PGS normal embryo means the chromosomes are normal, there is more to a baby than just chromosomes and sometimes it just doesnt work. Im sorry to hear that. END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? Causes of a chemical pregnancy. I had the biopsy done twice; one to test (which I was positive for) and one to ensure it was no longer present after a round of strong antibiotics. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . My first, was a success. First, PGS improves pregnancy rates. It wouldnt be going far at least. I go for my next Beta tomorrow. Sometimes something as small as a polyp that can be removed, can cause implantation to fail. Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. Ill have to ask my RE for options. Did our first FET in October with a supposedly PGT normal embryo. , ERA was a game changer for me! The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. We put both in and im currently 8weeks pregnant. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. Hoping to hear from them soon . You got this! They also provided information for the chance of getting no euploids per cycle: So as age increases, the chances of getting a euploid embryo drop. Sorry to hear about your recent cycle. Which was Claritin, pepcid, and baby aspirin. Then a frozen cycle BFN. This educational content is not medical or diagnostic advice. They found that: If you want to read my summary of this paper, check here. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Im hoping to do another transfer in January. We Tested the tissue and it was normal (??). If you did PGS after multiple miscarriages and failed attempts how many did you transfer? (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. Took THREE rounds of antibiotics for mine to clear. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. For women who have it, REs may suggest prednisone and lovenox after transfer. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound.